Liu Guosong and others found that supplementing magnesium ions can reduce anxiety

What should I do if anxiety symptoms occur? Professor Liu Guosong ’s laboratory at the Tsinghua University Life Science Joint Center reported for the first time in the world that increasing the level of magnesium ions in the brain not only enhances the brain ’s normal learning and memory capabilities, but also helps eliminate fear memory and reduce anxiety .

A paper published in the Journal of Neuroscience published on October 19, 2011 revealed that their research found that at the molecular level, increasing brain magnesium level can enhance the control of normal learning and memory in the brain. Function, however, it does not affect the function of the brain region in the brain that produces fear memory. This differential regulation leads to the improvement of brain magnesium not only to enhance normal learning and memory functions, but also to suppress negative emotions (such as fear memory).

According to reports, under normal circumstances, magnesium ions in the human body can be obtained through food intake. However, it is worth noting that with the process of industrialization, the fine processing of food leads to a decline in the magnesium content of food, and changes in diet structure lead to near Half of the population has insufficient magnesium intake. These results of Liu Guosong's laboratory suggest that increasing the intake of magnesium-rich foods (such as green leafy vegetables, nuts, sea vegetables, etc.) can not only improve the brain's learning and memory ability, but also help reduce the anxiety caused by stressful life symptom.

Effects of Elevation of Brain Magnesium on Fear Conditioning, Fear Extinction, and Synaptic Plasticity in the Infralimbic Prefrontal Cortex and Lateral Amygdala

Nashat Abumaria1, Bin Yin1, Ling Zhang1, Xiang-Yao Li2, Tao Chen2, Giannina Descalzi2, Liangfang Zhao1, Matae Ahn1, Lin Luo1, Chen Ran1, Min Zhuo2, and Guosong Liu1,3

Anxiety disorders, such as phobias and posttraumatic stress disorder, are among the most common mental disorders. Cognitive therapy helps in treating these disorders; however, many cases relapse or resist the therapy, which justifies the search for cognitive enhancers that might augment the efficacy of cognitive therapy. Studies suggest that enhancement of plasticity in certain brain regions such as the prefrontal cortex (PFC) and / or hippocampus might enhance the efficacy of cognitive therapy. We found that elevation of brain magnesium, by a novel magnesium compound [magnesium-l -threonate (MgT)], enhances synaptic plasticity in the hippocampus and learning and memory in rats. Here, we show that MgT treatment enhances retention of the extinction of fear memory, without enhancing, impairing, or erasing the original fear memory. We then explored the molecular basis of the effects of MgT treatment on fear memory and extinction. In intact animals, elevation of brain magnesium increased NMDA receptors (NMDARs) signaling, BDNF expression, density of presynaptic puncta, and synaptic plasticity in the PFC but, interestingly, not in the basolateral amygdala. In vitro, elevation of extracellular magnesium concentration increased synaptic NMDAR current and plasticity in the infralimbic PFC, but not in the lateral amygdala, suggesting a difference in their sensitivity to elevation of brain magnesium. The current study suggests that elevation of brain magnesium might be a novel approach for enhancing synaptic plasticity in a regional-specific manner leading to enhancing the efficacy of extinction without enhancing or impairing fear memory formation.

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